针对低空交通发展中，安全、效率与规模化发展目标难以协同的核心矛盾，通过引入城市免疫学理论，为构建具备韧性、自适应性与可持续性的低空交通系统提供理论框架和实践参考，以破解发展瓶颈。将包含“持续监测与精准识别”“分级响应与协同防御”“免疫记忆与长效保护”“动态平衡与精细调控”等在内的免疫机制，系统性地演绎并映射至垂直起降场、通信、能源及监管等关键基础设施的规划、设计与运行管理中。基于理论推演，提出了一系列低空交通发展对策建议，强调构建覆盖全域的实时感知网络，形成多层级风险协同响应架构，并实现系统的预测性优化与动态平衡（即交通免疫系统）。对策建议同时注重物理与数字边界的融合防护、面向未来的可扩展技术集成，以及保障各子系统高效协调的一体化通信与治理网络。研究表明，城市免疫学所蕴含的“免疫智能”为低空交通发展的范式革新提供了强有力的理论支撑。以此为指导构建的低空经济系统，能够有效应对动态环境中的已知与未知挑战，在多重目标间实现有机统一与动态平衡，推动低空经济从蓝图构想走向实际落地，从而验证了该理论在复杂系统中的实践指导价值。

This paper addresses the core contradiction in the development of low-altitude transportation, wherein the objectives of safety, efficiency, and large-scale deployment are difficult to achieve in a coordinated manner. By introducing the theory of Urbanimmunology, the study provides a theoretical framework and practical reference for constructing a resilient, adaptive, and sustainable low-altitude transportation system, thereby overcoming key developmental bottlenecks. The paper systematically elaborates on and maps immune mechanisms—including continuous monitoring and precise identification, hierarchical response and coordinated defense, immune memory and long-term protection, as well as dynamic balance and fine-grained regulation—onto the planning, design, and operational management of critical infrastructures such as vertiports, communications, energy systems, and regulatory frameworks. Based on theoretical analysis, the study proposes a series of development measures for low-altitude transportation, emphasizing the establishment of a real-time, comprehensive sensing network with full spatial coverage, the formation of a multi-tiered collaborative risk-response architecture, and the realization of predictive optimization and dynamic equilibrium across the system (i.e., transportation immune system). These measures also highlight the integrated protection of physical and digital boundaries, forward-looking and scalable technological integration, and the unified communication and governance networks to ensure efficient coordination among subsystems. The findings demonstrate that the "immune intelligence" embedded in Urbanimmunology provides robust theoretical support for a paradigm shift in low-altitude transportation development. Guided by this framework, a low-altitude economic system can effectively respond to both known and unknown challenges in dynamic environments, achieving organic integration and dynamic balance among multiple objectives. This, in turn, facilitates the transition of the low-altitude economy from conceptual planning to practical implementation, thereby validating the practical guiding value of Urbanimmunology in complex systems.