为加速自动驾驶技术在干线物流领域的规模化应用，系统梳理了干线物流面临的现实需求与发展难题，并从产业协同视角剖析技术、法规与政策、组织体系、商业模式、数据安全五方面存在的瓶颈与挑战。在此基础上，构建“技术-组织-政策-商业”四维联动框架，提出自动驾驶技术在干线物流中的渐进式落地路径：以车-路-云协同突破感知与控制的技术瓶颈，以产业联盟整合运力与数据资源，以权责闭环、分级路权、激励相容的政策体系破解法规难题，以“DaaS-TaaS-运力生态平台”三阶段商业模式实现成本拐点跨越，旨在推动自动驾驶干线物流的产业化发展。

To accelerate the large-scale application of autonomous driving technology in trunk logistics, this paper systematically reviews the practical needs and development problems faced by trunk logistics, and analyzes the challenges in technology, regulations and policies, organizational systems, business models, and data security from the perspective of industry collaboration. On this basis, a four-dimensional linkage framework of Technology-Organization-Policy-Business is constructed, and a progressive implementation path is proposed: breaking through the technological bottleneck of perception and control by vehicle-road-cloud collaboration, integrating transportation and data resources through industry alliances, solving regulatory problems through a policy system of rights and responsibilities closed-loop, graded road rights, and incentive compatibility, and achieving cost inflection point breakthrough via the three-stage business model of DaaS-TaaS-Transportation Ecosystem Platform. These approaches intend to collectively promote the industrial development of autonomous driving in trunk logistics.