In order to improve the level of automation, intelligence and refinement of vehicle management of express enterprises, solve the problems of management lag and extensive management mode of express vehicles, and further adapt to the needs of high-quality development of express industry, an express vehicles management and control platform was designed and established. At first, the safety of express vehicles and corresponding requirements of intelligent, digital and scientific management were analyzed. Then, according to the requirements of vehicle management and control, the platform functions of transportation monitoring visualization, transportation cost refinement, assessment and evaluation standardization were designed. By introducing Beidou Navigation Satellite System(BDS), intelligent identification of internet of vehicles, big data and other key technologies, the express vehicle management and control platform of "terminal+network+platform+customer" was constructed. At last, taking postal vehicles′ management and control as a case, the practicability of the platform was verified from the perspectives of transportation efficiency and transportation cost. The results show that the service efficiency of postal transport vehicles has increased by 40%, and the annual operating cost of vehicles has decreased by 3.5%, which indicates that the platform can interconnect the information of people, vehicles, roads and express, realize the visualization of the whole express transportation process, improve the efficiency of express transportation, reduce the transportation cost and improve the level of security control.