In order to improve the safety of road transportation of medical materials, using the dynamics simulation software of Trucksim, the coupling model of van type medical transport vehicle, road and crosswind was established. By changing the friction coefficient of the road, the road conditions in sunny, rainy, snowy and frozen days were simulated. The extreme value of the crosswind model was changed to simulate all kinds of wind speed levels, and the cargo quality was changed to simulate all kinds of medical supplies. The closed-loop simulation test of the common working conditions of the single transfer line was carried out, and the response output of the lateral displacement and the roll angle of the vehicle were obtained. The results show that the driving stability of the van type medical transport vehicle is positively correlated with the change of the road friction coefficient, and negatively correlated with the change of the cargo quality and the wind speed grade; under the condition of single transfer line with the road friction coefficient of 0.28 and the vehicle speed of 60km/h in snowy days, the lateral displacement of the vehicle reaches 4.5m, the vehicle is easy to exceed the lane, causing the risk of collision; under the high wind speed level, the probability of vehicle rollover is greatly increased; the influence of the change of the cargo quality on the stability of the vehicle is small as a whole.
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