A certain gap exists between the current asphalt mixture design method and the effective design of high-performance pavement materials required by the design concept of long-life pavement. In order to fulfill this research gap, the design of pavement materials urgently needs novel and practical research concepts and methods. It is well known that Materials Genome Initiative (MGI) technology is such an effective method for efficient design of materials. It can be used in the design and research of asphalt mixture to promote the research and development of high-performance asphalt pavement materials and the construction of long-life pavement. Given this, the core concept of material genome technology was introduced, the technical basis of using material genetics idea in asphalt mixture design was summarized, as well as the research progress of phase gene and structure gene of asphalt mixture. The application conception of material genetics idea in the research and development of asphalt mixture was put forward. This comprehensive review indicates that many advanced test methods, analysis methods and calculation theories have been applied to characterize the multi-scale characteristics of asphalt, aggregate and asphalt mixture, which lays an effective technical foundation for the application of MGI in asphalt mixture design. Based on the current development of road engineering in China, it is recommended that the application of asphalt mixture genome technology could focus on the following four aspects: the determination of asphalt mixture gene characteristic parameters, the establishment of asphalt mixture digital database, the establishment of asphalt mixture digital performance prediction platform and the establishment of asphalt mixture intelligent on-demand design platform. With the achievement of these four proposed goals, the design method and performance research of high-performance asphalt mixture could be gradually optimized.
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