The difference of setting time measured in laboratory with standard maintenance and con⁃ struction site for cement concrete was significant. In order to improve guiding of time of setting for ce⁃ ment concrete construction, the application of the maturity integral calculation method for cement con⁃ crete was analyzed through the establishment of maturity calculation model based on integral method, and then the accuracy of predicting setting time for cement concrete with ＂maturity-penetration resis⁃ tance＂ relation curve established on outdoor natural maintenance and indoor standard maintenance were compared. The results show that compared with vibrating type of temperature changes, the maturity inte⁃ gral calculation method is more suitable for parabolic type of temperature changes; grey relational analy⁃ sis of maturity-penetration resistance relationship shows that the integral method of maturity calculation has quite accuracy compared with the piecewise method; using standard test method for time of setting of concrete mixture by penetration resistance to determine the setting time is not reasonable, and applying the corresponding maturity to predict time of setting shows higher accuracy. Predicting time of setting with maturity conforms preferably to actual institute in cement concrete construction site, and maturity is recommended as technical index of measuring time of setting for cement concrete.